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SCAN 4.3 Solutions


Solutions: Below are some sample tools that are provided for each of the specific areas listed. These represent just a few of the features that are available.


Sensory Neuroscience


Auditory – The SCAN software with SynAmps/SynAmps2 amplifiers allows you to record very short latency ABRs, as well as all MLRs and MMNs. Online Fsp statistical analyses determine when significant signals are emerging.


Visual – In addition to accurate measurement of VEPs, also included are PCA/ICA and Source analyses to identify the specific components and dipole source solutions.


Somatosensory – Deblocking features in SCAN with SynAmps/SynAmps2 systems let you acquire data free from stimulus artifact. All sensory EPs can be mapped as 2D or 3D representations.



Cognitive Neuroscience


Language Processing – From detection of differences in speech sounds (the mismatch negativity), to symantic (N400), and syntactic (P600) incongruity in the auditory or visual modality, unique event coding and the online display of multiple sorted averages provide powerful options for investigating language processing in adults and children.


Attention – Combined with sorted averaging, online independent components analysis (ICA) can be used to objectively identify and measure neurophysiological responses associated with attentional vigilance and target detection such as the contingent negative variation (CNV) and the P300.


Memory – A variety of paradigms (e.g., spatial location, serial position recall) can be used to generate neurophysiological responses to investigate normal and impaired memory processes from registration, to recognition and recall.


Oscillatory Beta and Gamma Band Activities – Induced (non-stimulus locked) and evoked components of the fast cortical oscillations that have been correlated with higher order cognitive processing as well as perceptual binding evaluated and the strength of associations between cortical areas can be estimated in user-defined frequency bands using the eventrelated band pass and event-related coherence transforms in the Scan Analysis software.


In all of these cases, you will typically have a stimulus presentation system, such as STIM2, with unique coding to identify the various stimuli and responses. The SCAN software allows you to sort sweeps on the basis of the various stimuli and responses, and then create averages for each. This provides virtually unlimited flexibility for analyzing permutations of, for example, P300 paradigm studies.



Applied Neuroscience


Schizophrenia – From the relatively small, fast P50 component, to the larger, slower P300, the SCAN software provides all the tools needed to investigate these phenomena.


Epilepsy – Epileptic spikes can be back-averaged and combined with Source and Curry for multimodal neuroimaging analyses.


Learning Disorders / Attention Deficit Disorder – Paradigms can be constructed to assess sensory gating processing (P50) to higher order cognitive manifestations of these impairments in children and teens.


Alzhiemer’s Disease – Altered cortical function in Alzhiemer’s disease has been assessed using the Neuroscan suite of neurophysiological tools.


Sleep – Online spectral analysis can be used to determine sleep stages. Frequency based rejection or retention of data can be used to limit analysis to the spectrally-identified sleep stage of interest.


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SCAN 4.3

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